Nancy Pelosi, the trailblazing Democrat who made history as the first woman to serve as Speaker of the U.S. House of Representatives, announced Thursday that she will not seek reelection next year, bringing an end to a nearly four-decade career in Washington.

Pelosi, 85, has been a defining figure in American politics, guiding her party through pivotal moments and legislative victories. Her decision marks the conclusion of a remarkable tenure representing California’s deeply Democratic district that covers virtually all of San Francisco.

In her farewell statement, Pelosi reflected on her legacy, highlighting her role in passing landmark legislation such as the Affordable Care Act, climate laws, and COVID-19 stimulus packages. She also played a key role during the economic downturn of 2007-2009 and served as a powerful voice for progressive causes.

The race to succeed her is already shaping up, set against the backdrop of San Francisco’s ongoing housing crisis and debates over urban development. The district’s voter base is overwhelmingly Democratic, with Republicans making up just 7%.

Throughout her tenure, Pelosi became a symbol of Democratic resilience and leadership, often facing fierce opposition from Republicans, including President Donald Trump, who frequently targeted her in political battles.

As Pelosi prepares to step down at the end of her current term in early 2027, her influence on national policy and her role as a trailblazer for women in politics remain enduring legacies.