MCB-613 repairs heart tissues; may also prevent heart failure

Treatment with the chemical MCB-613 restores cardiac tissue after a severe heart attack in mice, reducing the damage that could lead to heart failure. The findings were presented virtually at ENDO 2021, the annual conference of the Endocrine Society.

“This is a remarkable discovery that may lead to effective and safe treatments to prevent the progression to heart failure after a heart attack,” said lead researcher Lisa K. Mullany, Ph.D., of Baylor College of Medicine in Houston.

Humans die due to heart failure after a heart attack. There is no definitive treatment for this except heart transplantation.

Previously researchers found that MCB-613 stimulates proteins called steroid receptor coactivators (SRCs). Such proteins help the growth during normal and abnormal tissue growth. It is also responsible for cellular changes.

Damaged tissue scars after a heart attack. This causes tissue loss, increased inflammation, scarring, and a reduction in heart function, all of which are symptoms of heart failure induced by a heart attack.

The new study reveals that after giving mice the MCB-613 within hours after they experienced a heart attack, the inflammation and scarring were decreased by the molecule, and preventing the heart from completely stop functioning.

“Our findings show us that we can directly modulate heart tissue repair to prevent heart failure,” Mullany said.

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